Jaap Keijer, PhD
Wageningen University
Human and Animal Physiology group (WU-HAP)
De Elst 1, PO Box 338
6700 AH  Wageningen, The Netherlands

Research of Human and Animal Physiology (HAP) is focused on energy metabolism. A compromised energy metabolism is a central component of diet- and age-related diseases and affects organ and tissue function. By studying energy metabolism, we want to improve metabolic health and prevent disease and dysfunction. We do this by physiological and molecular physiological research that aims at understanding the role of mitochondria and intermediary metabolism in metabolic health of vertebrates and how this can be improved by nutrients, compounds and physical activity. We perform experimental research in humans, animals (with emphasis on rodents and pigs), tissues and cells, using state-of-the-art physiological, molecular, biochemical and histological tools. Results of our research are (i) new mechanistic insights in metabolism related to health and organ functioning and, (ii) methodology and data to substantiate the efficacy of interventions, compounds and foods to improve metabolic health.

The group represented by its head J. Keijer, is a collaborator to the project. WU-HAP contributes long-standing, extensive experience in transcriptome analysis and interpretation, as well as ad-hoc samples that will be used for further characterisation of biomarkers identified in children and adolescents in the core cohort.